The citation register

BPC-157 References

Every quantitative claim on this site resolves to one of the entries below. Primary studies, reviews, and the FDA regulatory sources.

How to read this register

These are the BPC-157 references cited across the field station. Each inline [N] marker on the research, cytoprotection, dosage, legal-status and FAQ pages resolves to the matching number here. Entries carry a PubMed link, and a DOI where one exists; the regulatory entries link to the relevant FDA pages.

The register is deliberately mixed. It pairs the foundational primary studies — the 2003 transected-tendon work [1], the 2004 gastric-ulcer cytoprotection study [4], the 2017 VEGFR2 angiogenesis paper [3], the 2022 PK/ADME characterization [2] — with the three human pilots [6][10][14] and the recent 2024-2026 reviews and rodent studies [8][9][11][12][13][15]. The two FDA sources [16][17] anchor the regulatory page.

The literature is weighted heavily toward preclinical work, and a notable share of the foundational papers come from a single research group — a replication caveat the newer reviews state directly [11]. The three human pilots are listed alongside the animal studies so the human ceiling is visible in the register itself. Where a claim on this site carries a number, that number is here; where the site says "no data exist," no citation is offered because none should be.

  1. Staresinic M, et al. Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth. J Orthop Res. 2003;21(6):976-983.
  2. He L, et al. Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157, a potential drug for treating various wounds, in rats and dogs. Front Pharmacol. 2022;13:1026182.
  3. Hsieh MJ, et al. Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. J Mol Med (Berl). 2017;95(3):323-333.
  4. Xue XC, et al. Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats. World J Gastroenterol. 2004;10(7):1032-1037.
  5. Sikiric P, et al. Over-Dose Lithium Toxicity as an Occlusive-like Syndrome in Rats and Gastric Pentadecapeptide BPC 157. Biomedicines. 2021;9(11):1506.
  6. Lee E, Padgett B. Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain. Altern Ther Health Med. 2021.
  7. Multifunctionality and Possible Medical Application of the BPC 157 Peptide — Literature and Patent Review. Pharmaceuticals (Basel). 2025;18(2):185.
  8. Sikiric P, et al. Stable Gastric Pentadecapeptide BPC 157 as a Therapy and Safety Key: A Special Beneficial Effect Following Intoxications. Pharmaceuticals (Basel). 2025;18(6):928.
  9. Lee E, Burgess K. Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study. Altern Ther Health Med. 2025.
  10. McGuire FP, et al. Regeneration or Risk? A Narrative Review of BPC-157 for Musculoskeletal Healing. Curr Rev Musculoskelet Med. 2025.
  11. Tracheocutaneous Fistula Resolved by Pentadecapeptide BPC 157 Therapy Through the NO-System. Pharmaceuticals (Basel). 2026;19(1):145.
  12. Protective Effects of BPC 157 on Liver, Kidney, and Lung Distant Organ Damage in Rats with Acute Pancreatitis. Medicina (Kaunas). 2025;61(2):291.
  13. Lee E, Walker C, Ayadi B. Effect of BPC-157 on Symptoms in Patients with Interstitial Cystitis: A Pilot Study. Altern Ther Health Med. 2024.
  14. Sikiric P, et al. The Stable Gastric Pentadecapeptide BPC 157 Pleiotropic Beneficial Activity and Its Possible Relations with Neurotransmitter Activity. Pharmaceuticals (Basel). 2024;17(4):461.
  15. U.S. Food and Drug Administration. Bulk Drug Substances Used in Compounding Under Section 503A of the FD&C Act; and July 23-24, 2026 Meeting of the Pharmacy Compounding Advisory Committee (public agenda listing BPC-157, KPV, TB-500, and MOTs-C as substances being considered for inclusion on the 503A Bulks List). Verified 2026-05-29.
  16. U.S. Food and Drug Administration. Certain Bulk Drug Substances for Use in Compounding That May Present Significant Safety Risks (Category 2 entries for 'BPC-157 (free base)' and 'BPC-157 acetate', effective with the September 29, 2023 nominated-substances update). Verified 2026-05-29.